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1996-03-09
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Document 0151
DOCN M9650151
TI Lymphocyte subset counts in skin puncture and venous blood compared.
DT 9605
AU Cracknell SE; Hinchliffe RF; Lilleyman JS; University of Sheffield
Department of Paediatrics, Children's; Hospital, Western Bank.
SO J Clin Pathol. 1995 Dec;48(12):1137-8. Unique Identifier : AIDSLINE
MED/96165060
AB To determine whether skin puncture blood can be used reliably for CD4
lymphocyte counts, the numbers of the major subsets of lymphocytes were
assessed in paired venous and skin puncture blood samples from 22
children and 10 adults. Paired values were highly correlated, with skin
puncture values being about 7% higher than venous values for each cell
type. Differences were of borderline statistical significance for total
lymphocytes and for each subset except CD3+ CD8+ T lymphocytes.
Nevertheless, the magnitude of the differences was small and unlikely to
be of clinical importance, and it seems that skin puncture samples may
be preferable for CD4 counts in children or adults with difficult venous
access.
DE Acute Disease Adolescence Adult Blood Specimen Collection/*METHODS
Child Child, Preschool Comparative Study CD4 Lymphocyte Count Human
Infant Leukemia/IMMUNOLOGY Lymphocyte Count *Lymphocyte Subsets
Phlebotomy *Punctures Skin/*BLOOD SUPPLY CLINICAL TRIAL CONTROLLED
CLINICAL TRIAL JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).